POTENTIAL COMPOUND DERIVED FROM CATHARANTHUS ROSEUS TO INHIBIT NON SMALL CELL LUNG CANCER (NSCLC)

Abstract

The aim of this study was to carry out GC-MS analysis of Catharanthus roseus plant leaves extract to inhibit the non-small cell lung cancer. Catharanthus roseus plant leaves were extracted with methanol and five compounds were identified from GC-MS analysis. Epidermal growth factor receptor (EGFR), is a receptor tyrosine kinase (RTK) which is frequently over-expressed and malignant proliferation of non-small cell lung cancer (NSCLC). The 3D crystal structure of the non-small cell lung cancer responsible protein (ID: 2ITO) were retrieved from the protein data bank (PDB). Discovery studio is a well-known suite of software for molecular docking. It is developed and distributed by Accelrys. The protein ligand docking was performed in flexible docking by Discover Studio. From the GC-MS analysis two compounds 4-piperidineacetic,1-acetyl-5-ethyl-2-[3-[2hydroxyethyl]-1H-indol-2-yl]-a-methyl-methyl ester and 2H-Pyran,tetrahydro-2-[12-penta decynyloxy], exhibited potential effect against human epidermal growth factor receptor (EGFR) responsible for the non-small cell lung cancer.