Abstract
Background The renin-angiotensin system and endothelium-derived nitric oxide (EDNO) are important regulators of vascular tone. This study was designed to investigate endothelial and vascular smooth muscle function in coronary arteries of Ren-2 transgenic rats. Methods and Results Left anterior descending coronary arteries and aortas were isolated from transgenic rats and Sprague-Dawley control rats at 6 (young) and 12 (adult) weeks of age and examined in myographs or organ chambers for isometric tension recording. Systolic blood pressure was significantly higher in transgenic rats (young, 229±6 mm Hg; adult, 239±8 mm Hg) than in control rats (young, 126±2 mm Hg; adult, 118±3 mm Hg; P
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Tschudi, M. R., Noll, G., Arnet, U., Novosel, D., Ganten, D., & Lüscher, T. F. (1994). Alterations in coronary artery vascular reactivity of hypertensive Ren-2 transgenic rats. Circulation, 89(6), 2780–2786. https://doi.org/10.1161/01.CIR.89.6.2780
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