Melanopsin for Time-Controlling Activation of Astrocyte –Neuron Networks

Abstract

Melanopsin, a mammalian G-protein-coupled photopigment, is a novel optical tool which enables studying astrocyte–neuron networks. Here, we describe the required guidelines to take advantage of this promising optical tool for functional neuron–glia studies. The selective expression of melanopsin in astrocytes allows triggering astrocytic Ca2+ signaling, changes in synaptic transmission, and modifying behavioral responses.