Modelling the way Ku binds DNA

Abstract

Ku plays a crucial role in the non-homologous end joining pathway to repair DNA double-strand breaks. In this study, we modelled the full-length Ku heterodimer from the truncated crystal structure and NMR structure, and conducted a series of docking and molecular dynamics simulations in an effort to probe the structural, dynamical and energetic features of each domain in free Ku and Ku-DNA complexes. Published by Oxford University Press on behalf of the US Government 2010.