Introduction: Allergy to penicillins is commonly self-reported in community and hospitalised patients. The majority of these patients with a “penicillin allergy label” (AAL) are not allergic and will tolerate penicillins after appropriate assessment (“de-labelling”). Patients with AALs require more broad-spectrum antibiotics, significantly longer inpatient stays and more hospital readmissions. There is a clinical need to standardise our approaches of antibiotic de-labelling in order to prevent the unnecessary restriction of antibiotic options, negative clinical outcomes and associated health economic costs. Method: In 2014 the ASCIA Drug Allergy Working Party was formed and developed a consensus statement for assessment of IgE mediated penicillin allergy, which was based on current literature and expert opinion. In 2015 this statement was reviewed by the 35 members of the ASCIA Drug Allergy Working Party and the ASCIA membership. Results: The ASCIA consensus statement for assessment of IgE mediated penicillin allergy incorporates management algorithms for patients with low and high probability of true penicillin allergy. It differs from the European and American protocols as skin testing is omitted in the de-labelling process of subjects with low probability of penicillin allergy. A pre-clinic questionnaire is included to assist with the triage process and review of patients in clinics. Data relating to the performance of protocols are currently being collected and preliminary data from this audit will be presented. Conclusion: The ASCIA consensus statement provides evidence-based information for those managing patients with a penicillin allergy label, protocols for skin testing and guidance on when to challenge with the aim of de-labelling patients who do not have IgE mediated penicillin allergy. This statement should enable standardised management of penicillin allergy and provide a foundation for the wider application of penicillin allergy delabelling in medical clinics throughout Australia and New Zealand.
CITATION STYLE
Lucas, M., Smith, W., Vale, S., Smith, J., & Katelaris, C. (2016). ASCIA‐P43: ASCIA CONSENSUS STATEMENT FOR ASSESSMENT OF IMMEDIATE (IgE MEDIATED) PENICILLIN ALLERGY. Internal Medicine Journal, 46(S4), 18–18. https://doi.org/10.1111/imj.43_13197
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