Mammalian neuro endocrinological changes and oxidative stress during chronic lead intoxication

Abstract

The dangerous effect of lead was evaluated in male mice exposed to lead acetate at dose 2000 and 4000 ppm in drinking water, as well as subjects working in fields with high lead levels. Lead exposure exhibited marked decrease in body weight, as well as in hematological parameters such as hemoglobin content, hematocrit percent, erythrocytes and leucocytes count. In addition, there was a disruptive effect on neurological and endocrinological systems reflected by alterations in T3, T4, testosterone and cortisol hormones. In contrast, there was an elevation in serotonin level, along with a reduction in the concentrations of plasma Zn and Fe in lead exposed mice and human individuals. The study showed increases in the lipid peroxidation product (MDA), accompanied with decreases in GSH and SOD in lead exposed subjects and animals. The study thus indicated that exposure to lead pollution should be avoided as it affect neuro-endocrinological systems, increases oxidative stress and decreases fertility. © 2013 Edrees G, et al.