Transcription factor Reb1p regulates DGK1-encoded diacylglycerol kinase and lipid metabolism in saccharomyces cerevisiae

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Abstract

Background:Diacylglycerol kinase produces phosphatidate, a major precursor for the synthesis of membrane phospholipids. Results:The expression of diacylglycerol kinase is induced by the Reb1p transcription factor, and the resulting activity increase is essential for the enzyme function in phospholipid synthesis. Conclusion:The Reb1p-mediated transcriptional activation regulates the expression of diacylglycerol kinase activity. Significance:Diacylglycerol kinase is regulated at the level of transcription. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Qiu, Y., Fakas, S., Han, G. S., Barbosa, A. D., Siniossoglou, S., & Carman, G. M. (2013). Transcription factor Reb1p regulates DGK1-encoded diacylglycerol kinase and lipid metabolism in saccharomyces cerevisiae. Journal of Biological Chemistry, 288(40), 29124–29133. https://doi.org/10.1074/jbc.M113.507392

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