Matrix metalloproteinases in acute lung injury

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases belonging to the metzincin superfamily of metalloproteinases. MMPs can degrade most of the components of the extracellular matrix and basement membrane. In addition, these enzymes can cleave some inflammatory mediators. This variety of substrates gives MMPs a wide number of functions during physiologic and pathologic processes. In this sense, many of the MMPs are not expressed in normal tissues, but expression and activity increases dramatically during matrix turnover, inflammation and repair. © 2007 Springer Science + Business Media Inc.