MOR23 Promotes Muscle Regeneration and Regulates Cell Adhesion and Migration

Citations of this article
Mendeley users who have this article in their library.


Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro, two processes common during tissue repair. A soluble ligand for MOR23 is secreted by muscle cells in vitro and muscle tissue in vivo. MOR23 is necessary for proper skeletal muscle regeneration as loss of MOR23 leads to increased myofiber branching, commonly associated with muscular dystrophy. Together these data identify a functional role for an OR outside of the nose and suggest a larger role for ORs during tissue repair. © 2009 Elsevier Inc. All rights reserved.

Author supplied keywords




Griffin, C. A., Kafadar, K. A., & Pavlath, G. K. (2009). MOR23 Promotes Muscle Regeneration and Regulates Cell Adhesion and Migration. Developmental Cell, 17(5), 649–661.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free