Unsaturated oxazolopiperidone lactams: An unexpected dominotype double conjugate addition-cyclization process

Abstract

Reactions of 2-acetylindole enolate with unsaturated oxazolopiperidones 3, 4 and 10 unexpectedly gives pentacyclic dilactams 6, 7 and 11, respectively, resulting from a domino-type process involving two successive conjugate additions and a final cyclization. © ARKAT-USA, Inc.