Given the gene orders in two modern genomes, it may be difficult to decide if some genes are close enough in both genomes to infer some ancestral proximity or some functional relationship. Current methods all depend on arbitrary parameters. We explore a two-parameter class of gene proximity criteria, and find natural values for these parameters. One has to do with the parameter value where the expected information contained in two genomes about each other is maximized. The other has to do with parameter values beyond which all genes are clustered. We analyse these using combinatorial and probabilistic arguments as well as simulations. © 2009 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Yang, Z., & Sankoff, D. (2009). Natural parameter values for generalized gene adjacency. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5817 LNBI, pp. 13–23). https://doi.org/10.1007/978-3-642-04744-2_2
Mendeley helps you to discover research relevant for your work.