Non-invasive assessment of early cardiac involvement in systemic sclerosis

Abstract

Twenty-eight patients with wide spectrum organ involvement of progressive systemic sclerosis but without signs or symptoms suggestive of cardiac involvement were studied by non-invasive cardiac techniques. The 12-lead electrocardiogram showed abnormalities in 6 patients: one had abnormal T waves and 5 had complete or incomplete right bundle branch block. Twenty four hour ambulatory electrocardiography demonstrated higher average heart rates than in similar aged controls (82 ± 9 vs 74 ± 9 beats/min, P<0.05). In one patient a short run ofventricular tachycardia was recorded. No other significant arrhythmia was documented. Echocardiographic measurements were within normal ranges but small pericardial effusions were observed in two patients (7%). Resting first pass radionuclide angiography, utilizing 12 mCi of technetium 99m were performed in 23 patients. Seven patients (30%) had abnonnal wall motion (diffuse hypokinesia), with a significant decrease in ejection fraction in comparison to those with normal wall motion (44 ± 6% vs 60 ± 6% P<0.01). Those with abnormal wall motion had suffered the disease longer than those with normal wall motion (13 ± 4 vs 9.5 ± 7 y). In conclusion, the heart is involved in half of the patients in this series; non-invasive cardiac assessment is useful in disclosing the early cardiac involvement and may influence long-term management. © The Fellowship of Postgraduate Medicine, 1985.