The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology. © 2011 Shin and Loewen; licensee BioMed Central Ltd.
CITATION STYLE
Shin, J. J. H., & Loewen, C. J. R. (2011, December 2). Putting the pH into phosphatidic acid signaling. BMC Biology. https://doi.org/10.1186/1741-7007-9-85
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