Endometrial regenerative cells and exosomes thereof for treatment of radiation exposure

Abstract

In 2007, we discovered a novel subset of mesenchymal stem cells (MSCs) derived from the endometrium, termed “endometrial regenerative cells (ERC).” In comparison to other MSC types (e.g., bone marrow and adipose), ERC possess (a) more rapid proliferative rate, (b) higher levels of growth factor production (VEGF, GM-CSF, PDGF), and (c) higher angiogenic activity. We are currently running two clinical trials for these cells in patients with critical limb ischemia and heart failure.