Computationally assisted engineering of protein cages

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Abstract

A hybrid computational method incorporating topographic analysis of protein surfaces and free-energy calculations of protein-protein interactions in protein nanocages is described. This design strategy can be used to engineer protein cages for enhanced structural stability and assembly.

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Ardejani, M. S., & Orner, B. P. (2015). Computationally assisted engineering of protein cages. Methods in Molecular Biology, 1252, 51–59. https://doi.org/10.1007/978-1-4939-2131-7_5

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