Increased corticomuscular coherence and brain activation immediately after short-term neuromuscular electrical stimulation

Abstract

Neuromuscular Electrical Stimulation (NMES) is commonly used in motor rehabilitation for stroke patients. It has been verified that NMES can improve muscle strength and activate the brain, but the studies on how NMES affects the corticomuscular connection are limited. Some studies found an increased corticomuscular coherence (CMC) after a long-term NMES. However, it is still unknown about CMC during NMES, as relatively pure EMG is very difficult to obtain with the contamination of NMES current pulses. In order to approach the condition during NMES, we designed an experiment with short-term NMES and immediately captured data within 100 s. The repetition of wrist flexion was used to realize static muscle contractions for CMC calculation and dynamic contractions for event-related desynchronization (ERD). The result of 13 healthy participants showed that maximal values (p = 0.0020) and areas (p = 0.0098) of CMC and beta ERD were significantly increased immediately after NMES. It was concluded that a short-term NMES can still reinforce corticomuscular functional connection and brain activation related to motor task. This study verified the immediate strengthen of corticomuscular changes after NMES, which was expected to be the basis of long-term neural plasticity induced by NMES.