Intracellular free iron and its potential role in Ultrahigh-pressure- induced inactivation of Escherichia coli

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Abstract

Intracellular free iron of Escherichia coli was determined by whole-cell electron paramagnetic resonance spectrometry. Ultrahigh pressure (UHP) increased both intracellular free iron and cell lethality in a pressure-dose-dependent manner. The iron chelator 2,2=-dipyridyl protected cells against UHP treatments. A mutation that produced iron overload conditions sensitized E. coli to UHP treatment.

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Yan, Y., Waite-Cusic, J. G., Kuppusamy, P., & Yousef, A. E. (2013). Intracellular free iron and its potential role in Ultrahigh-pressure- induced inactivation of Escherichia coli. Applied and Environmental Microbiology, 79(2), 722–724. https://doi.org/10.1128/AEM.02202-12

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