Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.
CITATION STYLE
Thomas, D., Gaspar, D., Sorushanova, A., Milcovich, G., Spanoudes, K., Mullen, A. M., … Zeugolis, D. I. (2016, June 1). Scaffold and scaffold-free self-assembled systems in regenerative medicine. Biotechnology and Bioengineering. John Wiley and Sons Inc. https://doi.org/10.1002/bit.25869
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