Abstract
In the course of our screening program for regulators of circadian clock system (circadian rhythms), we isolated a new natural compound JBIR-26 (1) from Streptomyces sp. AK-AH76. The structure was determined to be 2-hydroxy-3,6-dimethylbenzoic acid on the basis of spectroscopic data. Compound 1 lengthened the period-length of mammalian clocks for 1.5 hours at a concentration of 10-μ/ml. © Japan Antibiotics Research Association.
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Izumikawa, M., Ukai, H., Takagi, M., Ueda, H. R., & Shin-ya, K. (2008). JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates Mammalian circadian clock. Journal of Antibiotics, 61(12), 756–758. https://doi.org/10.1038/ja.2008.90
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