Abstract
A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity. © 2012 The Pharmaceutical Society of Japan.
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Kunda, U. M. R., Balam, S. K., Nemallapudi, B. R., Chereddy, S. S., Nayak, S. K., & Cirandur, S. R. (2012). Facile synthesis, antioxidant and antimicrobial activity of amino methylene bisphosphonates. Chemical and Pharmaceutical Bulletin, 60(1), 104–109. https://doi.org/10.1248/cpb.60.104
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