With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
CITATION STYLE
Walmsley, S. R., Chilvers, E. R., & Whyte, M. K. B. (2009). Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Research & Therapy. https://doi.org/10.1186/ar2632
Mendeley helps you to discover research relevant for your work.