A T suppressor cell population that specifically shut down delayed hypersensitivity responses (DHR) to the parasite was found in both BALB/c mice chronically infected with Leishmania mexicana pifanoi and in naive mice which had received a single IV supraoptimal dose of killed parasites. At the early phase of infection mice exhibited a transitory state of cell-mediated immunity against the parasite that was abrogated when lesions reached their accelerated phase of growth. Results suggest that in both infected and high-dose immunized mice, the activation of T suppressor cells of DHR is related to antigen overload.
CITATION STYLE
Pérez, H. A., Henriquez, M., & de la Rosa, M. (1985). Activation of suppressor cells of the delayed hypersensitivity response in BALB/c mice infected or immunized with Leishmania mexicana pifanoi. Memórias Do Instituto Oswaldo Cruz, 80(4), 429–438. https://doi.org/10.1590/s0074-02761985000400008
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