Structure Determination of Ribosylated Rifampicin and Its Derivative: New Inactivated Metabolites of Rifampicin by Mycobacterial Strains

Abstract

Rifampicin (1) was converted into two inactivated products RIP-Ma and RIP-Mb by Mycobacterium smegmatis DSM43756. MS, NMR and chromatographic analysis showed the compounds to be 3-formyl-23-[0-(α-D-ribofuranosyl)]rifamycin SV (6) and 23-[O-(α-D-ribofur-anosyl)]rifampicin (7), respectively. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.