Ameliorative Role of Nutraceutical Quercetin and its Derivatives Against Cognitive Impairment Process Induced by Lead Exposure in Drosophila melanogaster(Fruit Fly)

Abstract

Cumulative lifetime lead (Pb) exposure has been associated with accelerated declines in cognition through free radical generation and epigenetic effects.Several literature has established the link between lead exposure and neurodegenerative disorders.Harwich strain of drosophila Melanogaster were exposed to lead acetate for two weeks and the changes in impulse transmission through acetylcholinesterase and systemic redox state were assessed. In addition, molecular docking studies of acetylcholinesterase against quercetin was carried out. In silico toxicity, pharmacokinetics studies on quercetin were also carried-out. The data obtained showed alteration in function of antioxidant enzymes and molecules such as catalase, glutathione-S-transferase and glutathione. Up regulation of acetylcholinesterase activity was observed following treatment with quercetin. Molecular docking studies revealed quercetin to bind to both active and peripheral pocket of acetylcholinesterase. Pharmacokinetic studies show moderate solubility, high therapeutic index, excellent absorption capacity, hepatoprotective and non-mutagenic properties. Therefore, quercetin alongside other antioxidant molecules can play a vital role in preventing the onset of Alzheimer and antioxidant related disorders.