Coronary artery ligation to induce myocardial infarction (MI) and ischemia/reperfusion (I/R) injury in mice is typically performed by an invasive and time-consuming approach that requires ventilation and a full thoracotomy (classical method), often resulting in extensive tissue damage and high mortality. Here, we describe a novel and rapid surgical method to induce MI that does not require ventilation. This method is much more efficient and safer than the classical method of MI and I/R injury. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Gao, E., & Koch, W. J. (2013). A novel and efficient model of coronary artery ligation in the mouse. Methods in Molecular Biology, 1037, 299–311. https://doi.org/10.1007/978-1-62703-505-7_17
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