Total synthesis of the antifungal agent echinocandinc

Abstract

Reliably stable: A dipeptide building block with fully elaborated N-acyl hemiaminal proved to be a versatile precursor for echinocandinC, a prototypical member of the echinocandin group of antimycotic drugs. This first total synthesis of an N-acyl hemiaminal-containing echinocandin is concise and highly convergent, thereby making additional derivatives easily accessible. PG=protecting group. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.