Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. Changes in H-2 gene expression have now been correlated with disease resistance in a variety of viral systems. The experiments discussed indicate that viruses may directly or indirectly affect H-2 antigen expression at various levels of gene expression. These investigations generate a framework for approaching a molecular understanding of viral-induced changes in H-2 gene expression.
CITATION STYLE
Brown, G. D., Choi, Y., Pampeno, C., & Meruelo, D. (1988). Regulation of H-2 class I gene expression in virally transformed and infected cells. Critical Reviews in Immunology. https://doi.org/10.1007/978-1-4757-0764-9_62
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