Improving outcomes after relapse in Ewing's sarcoma: Analysis of 114 patients from a single institution

Abstract

The outcome for patients with relapsed Ewing's sarcoma is poor. A retrospectiveanalysis was carried out to identify factors associated with improved survival.Between 1992 and 2002, 114 patients presented with relapsed or progressive disease.Median time to progression/relapse was 13 months (range, 2-128). Treatment atrelapse included high dose treatment (HDT) in 29 patients, and surgery or definitiveradiotherapy in 29. 2 and 5-year post relapse survival (PRS) was 23.5% and 15.2%,respectively. In multivariate analysis, the most significant factors associated withimproved survival were disease confined locally or to the lungs (2-year PRS, 40%versus 6%; P 18 months from diagnosis (2-year PRS, 53% versus8%; P