Laser Light Scattering Characterization of Special Intractable Macromolecules in Solution

Abstract

This review summerizes the recent advances in characterization of some special intractable macromolecules in solution by laser light scattering. Since both static and dynamic laser light scattering (LLS) are theoretically well established, we focus the discussion on experimental details, such as the design of a high-temperature LLS spectrometer, the sample clarification, a novel differential refractometer, and some newly developed methods for data analysis which include a combination of static and dynamic LLS leading to molar mass distribution determination and LLS calibration of gel permeation chromatography.