Background: Elective knee surgery is performed to reduce chronic pain and improve function in degenerate knees. Treatment of acute post-operative pain is suboptimal in 75% of patients despite multimodal analgesic approaches resulting in higher post-operative opiate consumption. The effect of corticosteroids as an adjunct for post-operative pain control remains undefined. Methods: The databases MEDLINE, EMBASE and CENTRAL (Cochrane library) will be searched from their inception to present using broad search criteria for eligible randomised/quasi-randomised controlled trials investigating perioperative corticosteroid adjunctive use in elective knee surgery. Meta-analyses will be conducted according to the recommendations from the Cochrane Handbook for Systematic Reviews of Interventions. Discussion: This systematic review of the perioperative adjunctive use of corticosteroids will assess the analgesic effects, post-operative nausea and vomiting, opiate consumption, infection rates and time till discharge and assess whether adjunctive corticosteroids should be encouraged in elective knee surgery. Systematic review registration: PROPSERO CRD42016049336
CITATION STYLE
Mohammad, H. R., Trivella, M., Hamilton, T. W., Strickland, L., Murray, D., & Pandit, H. (2017). Perioperative adjuvant corticosteroids for post-operative analgesia in elective knee surgery - A systematic review. Systematic Reviews, 6(1). https://doi.org/10.1186/s13643-017-0485-8
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