Stress & the microbiota–gut–brain axis in visceral pain

  • Moloney R
  • Dinan T
  • Cryan J
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Abstract

Visceral pain is a global term used to describe pain originat- ing from the internal organs of the body, which affects up to 25% of the population and is a common feature of functional gastroin- testinal disorders (FGIDs) such as irritable bowel syndrome (IBS). While IBS is multifactorial, with no single etiology to completely explain the disorder, many patients also experience co-morbid behavioral disorders, such as anxiety or depression, thus IBS is described as a biopsychosocial disorder of the gut-brain axis. Cur- rently, treatment strategies are unsatisfactory, with development of novel therapeutics hindered by a lack of detailed knowledge of the underlying mechanisms. The pathophysiology of visceral pain strongly implicates a role of stress in the development and exacer- bation of symptoms. In this presentation, I will discuss our recent studies in a vari- ety of rodent models of visceral pain, in particular early-life stress models as well as genetic susceptibility models. I will describe our data, demonstratinghowstress can modify central pain circuitry at the level of the spinal cord, highlighting a key role of glutamater- gic signaling. Furthermore, I will discuss the potential of employing epigenetic modifiers, specifically histone deacetylase inhibitors, as a treatment strategy for visceral pain. More recently, the role of the gut microbiota in the bi-directional communication along the gut-brain axis have been appreciated. I will present data to further support a novel role of the gut microbiota in the regulation of vis- ceral pain processes. Taken together, these findings will enhance our knowledge of the pathophysiology of visceral pain.

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Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015). Stress & the microbiota–gut–brain axis in visceral pain. Psychoneuroendocrinology, 61, 8. https://doi.org/10.1016/j.psyneuen.2015.07.408

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