Neuropilin-1 in immune-mediated diseases

Abstract

In recent years, it was realized that NP-1 is important for maintaining normal immune response homeostasis. It was found that NP-1 is highly expressed on both murine and human T regulatory cells (Tregs), thus increasing Treg cell properties, especially their contribution to the maintenance of self-tolerance [4]. Little is known today regarding the contribution of NP-1 in autoimmunity. In this section we will discuss the role of NP-1 in several autoimmune/immune mediated diseases. We will focus mainly on its regulatory/protective role in autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), which are prototypic autoimmune diseases.