Fold recognition is concerned with the prediction of protein three-dimensional structure from amino acid sequence by the detection of extremely remote homologous or analogous relationships to known structures. As such it lies midway between ab initio protein folding and close homology modelling. This chapter surveys both the history of the field and the current state-of-the art, focussing on approaches recently shown to be successful in international blind trials.
CITATION STYLE
Kelley, L. A. (2017). Fold recognition. In From Protein Structure to Function with Bioinformatics: Second Edition (pp. 59–90). Springer Netherlands. https://doi.org/10.1007/978-94-024-1069-3_3
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