The role of 11β-hydroxysteroid dehydrogenase activity in the metabolic syndrome: Lessons learned from the animal model

Abstract

In summary, we learn from the exciting study on 11β-HSD1 transgenic mice that tissue-specific glucocorticoid-dependent adipocyte pathways have a major impact on systemic metabolism and may provide a possible new target for the treatment of visceral obesity and the metabolic syndrome in humans.