Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy

  • Kondoh N
  • Mizuno-Kamiya M
  • Takayama E
  • et al.
10Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

© 2018 Kondoh et al. Introduction: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. Methodology: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets. Conclusion: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.

Cite

CITATION STYLE

APA

Kondoh, N., Mizuno-Kamiya, M., Takayama, E., Kawati, H., Umemura, N., Yamazaki, Y., … Tohnai, I. (2018). Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy. The Open Dentistry Journal, 12(1), 455–465. https://doi.org/10.2174/1874210601812010455

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free