© 2018 Kondoh et al. Introduction: In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression. Methodology: During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets. Conclusion: In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.
CITATION STYLE
Kondoh, N., Mizuno-Kamiya, M., Takayama, E., Kawati, H., Umemura, N., Yamazaki, Y., … Tohnai, I. (2018). Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy. The Open Dentistry Journal, 12(1), 455–465. https://doi.org/10.2174/1874210601812010455
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