Four new triterpenes from fungus of fomes officinalis

Abstract

In the previous work we reported five lanostane-type triterpenes from the CHCl3 soluble fraction of Fomes officinalis. In further study on the isolation of constituents from the CHCl3 soluble fraction, four new triterpenes, fomefficinic acids F (1), G (2) and fomefficinols A (3), B (4), together with seven known compounds officinalic acid (5), fomlactone A (6), fomlactone B (7), fomlactone C (8), laricinolic acid (9), ergosterol (10), ergota-7,22,dien-3 β-ol (11) were isolated. The structures of new compounds were determined by spectroscopic analyses and chemical methods including NMR spectroscopic techniques (13C, 1H, heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bonding correlation (HMBC), correlation spectroscopy (COSY) and nuclear Overhauser effect spectroscopy (NOESY)). © 2009 Pharmaceutical Society of Japan.