Microwave-assisted synthesis of (±) -mandelic acid- d 5, optical resolution, and absolute configuration determination

2Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

An efficient microwave-assisted synthesis of (±) -mandelic acid- d 5 was developed. The racemic mixture was resolved by diastereomeric salt formation using 1-phenylethylamine enantiomers as resolving agents. At each step, the resolution process was checked by determining mandelic acid- d 5 enantiomer ee values directly on fractional crystallized diastereomeric salts by chiral capillary electrophoresis analysis. Highly enriched (-)- and (+)-mandelic acid- d 5 (95 and 90 ee, resp.) were obtained and their absolute configurationsR and S, respectivelywere determined by correlation of the (-)-mandelic acid- d 5 circular dichroism spectrum to the (R)-mandelic acid one. © 2013 Claudio Bruno et al.

Cite

CITATION STYLE

APA

Bruno, C., Lentini, G., Lovece, A., Cavalluzzi, M. M., Carocci, A., Catalano, A., & Franchini, C. (2013). Microwave-assisted synthesis of (±) -mandelic acid- d 5, optical resolution, and absolute configuration determination. Journal of Chemistry. https://doi.org/10.1155/2013/386238

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free