Global Effects of Ras Signaling on the Genetic Program in Mammalian Cells

Abstract

While target genes deregulated by oncogenic Ras signaling were identified in a low-throughput manner in the past, recent expression profiling technologies have permitted transcriptome-wide screening approaches. The number of known deregulated genes has increased substantially, as has the proportion of candidate genes involved in various aspects of Ras-induced transformation. This chapter summarizes the results of gene expression profiling studies based on microarrays and advanced cDNA subtraction procedures