The effect of progesterone as a respiratory stimulant in newborn subjects is less known than that in adults. This study investigated the dose-response curve (0, 2, 4, and 8 mg/kg, ip) of progesterone on ventilation in non-anesthetized newborn rats at 4- and 12-days old using plethysmo-graphy. Progesterone had no effects in the regulation of normoxic ventilation. However, it enhanced the response to moderate hypoxia (FiO2 12%, 20 min) in 4- but not in 12-days old pups. This response was similar between the dose of 4 and 8 mg/kg. These observations suggested that progesterone enhances in age- and dose-dependent manner the hypoxic ventilatory response in newborn rats. © Springer Science+Business Media Dordrecht 2012.
CITATION STYLE
Hichri, O., Laurin, J. C., Julien, C. A., Joseph, V., & Bairam, A. (2012). Dose dependent effect of progesterone on hypoxic ventilatory response in newborn rats. In Advances in Experimental Medicine and Biology (Vol. 758, pp. 43–48). Springer Science and Business Media, LLC. https://doi.org/10.1007/978-94-007-4584-1_6
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