Aberrant cytokine production by nonmalignant cells in the pathogenesis of myeloproliferative tumors and response to jak inhibitor therapies

Abstract

Kleppe and colleagues use detailed cytokine profi ling analyses to investigate the role of aberrant proinfl ammatory cytokine secretion in the pathogenesis of myeloproliferative neoplasms. Their analyses implicate constitutive activation of STAT3 in both malignant and nonmalignant bone marrow cell populations as a driver of aberrant cytokine secretion and as a cellular target mediating the therapeutic activity of ruxolitinib.Cancer Discov; 5(3); 234–6. ©2015 AACR.