The interaction of glutathione and thymoquinone and their antioxidant properties

Abstract

Protein S-glutathionylation has been regarded as one of the main mechanisms that control cell signaling and metabolic regulation. Several diseases including cardiovascular diseases, diabetes, neurodegenerative diseases and many types of cancer have been certainly found to be related with S-glutathionylation. It can be regarded as a promising area for therapeutic and diagnostic approaches in many diseases. In this mini review, we aimed to summarize and compare the interaction of glutathione (GSH) and thymoquinone (TQ), and elucidate the possible synergistic mechanisms of antioxidant and other beneficial effects.