Synthesis of Phenylurea Derivatives & Their Evaluation as Antihyperglycaemic Agents

Abstract

Literature survey reveals that in past few decades, some urea derivatives have been synthesized for the management of DM among which sulphonylurea have been gaining considerable recognition in the management of DM worldwide. In the present study N-phenyl-.N-(substituted) phenoxy acetyl ureas were synthesized using three- step reaction pathway. A new series of phenylurea's were prepared by treating phenylurea with chloroacetyl chloride to form the product which on further treatment with various substituted phenols gave the final product. All synthesized compounds were characterized on the basis of M.P range, RF value, elemental analysis, IR, NMR spectral analysis. Out of the compounds tested few showed antihyperglycaemic activity. © 2011 IGJPS. All rights reserved.