Risks factors in premature ejaculation: The neurological risk factor and the local hypersensitivity

Abstract

The varying patterns of premature ejaculation (PE), along with their types and severity, suggest that they might have differing pathogenesis. The possibility exists that the neurological disorders are involved in the pathogenesis of PE either through direct enhancement of the normal neurophysiologic mechanisms or by producing endocrine, metabolic or psychological changes that could induce PE. It may also be that the co-morbidities that can induce neurologic disorders predispose in some way to the development of PE. The reported neurological risk factors of PE include traumatic brain injury, cerebrovascular disease, Parkinson's disease and epilepsy, multiple sclerosis, spinal cord lesions and penile hypersensitivity. In virtually all studies, the strength of the associations is not estimated and many of the studies are anecdotal reports. Neurological disease remains an important risk factor in PE, and there is an urgent need to develop novel diagnostic and therapeutic strategies to reduce this risk. More research, both experimental and on human, will be needed to sort out either the slowly emerging or the rapidly developing PE and complex picture of the pathogenesis of PE and different neurological disorders.