The 1-oxido-4-pyridyl radical generated by the reaction of 4-aminopyridine 1-oxide with amyl nitrite reacted smoothly with aromatic hydrocarbons, including five-membered heterocycles, i.e. thiophene, furan and pyrrole, to give the arylated products when acetic acid was used as the solvent. The relative rates of reaction with the l-oxido-4-pyridyl radical indicated that this radical is electrophilic, and this finding was supported by a comparison of molecular orbital energy levels. 2-Aminopvridine 1-oxide also undergoes a similar reaction. © 1984, The Pharmaceutical Society of Japan. All rights reserved.
CITATION STYLE
Saeki, S., Kondo, S., Hayashi, T., & Hamana, M. (1984). Studies on Tertiary Amine Oxides. LXXVII.1) The Pseudo-Gomberg Reaction of 4- and 2-Aminonvridine 1-Oxides. Chemical and Pharmaceutical Bulletin, 32(5), 1780–1789. https://doi.org/10.1248/cpb.32.1780
Mendeley helps you to discover research relevant for your work.