“On-Water” Catalyst-Free Ecofriendly Synthesis of the Hantzsch Dihydropyridines

Abstract

An eco-friendly “on-water” protocol for efficient catalyst-free synthesis of the Hantzsch dihydropyridines from aryl, heteroaryl, alkyl, and vinylogous aldehydes has been developed with minimum auxiliary substances, toxic reagents, organic solvents, and disposal problems.