Cancer-associated fibroblasts (CAFs) are a predominant stromal cell population in the tumour microenvironment. Here, the authors demonstrate that αSMA + CAFs can form an immunological synapse with regulatory T cells (Tregs) in tumours, which results in Treg activation and expansion in a process that is antigen- and autophagy-dependent.
CITATION STYLE
Varveri, A., Papadopoulou, M., Papadovasilakis, Z., Compeer, E. B., Legaki, A. I., Delis, A., … Verginis, P. (2024). Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49282-1
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