Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development

9Citations
Citations of this article
37Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Cancer-associated fibroblasts (CAFs) are a predominant stromal cell population in the tumour microenvironment. Here, the authors demonstrate that αSMA + CAFs can form an immunological synapse with regulatory T cells (Tregs) in tumours, which results in Treg activation and expansion in a process that is antigen- and autophagy-dependent.

Cite

CITATION STYLE

APA

Varveri, A., Papadopoulou, M., Papadovasilakis, Z., Compeer, E. B., Legaki, A. I., Delis, A., … Verginis, P. (2024). Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49282-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free