Chronic invasive Aspergillus sinusitis and otitis with meningeal extension successfully treated with voriconazole

Abstract

Invasive aspergillosis (IA) is a severe disseminated fungal disease that occurs mostly in immunocompromised patients. However, central nervous system IA, combining meningitis and skull base involvement, does not occur only in groups with classic risk factors for IA; patients with chronic renal failure and diabetes mellitus are also at risk for more chronic forms. In both of our proven IA cases, voriconazole monotherapy was effective without surgery, and cerebrospinal fluid and serum 1,3-β-D-glucan test results were initially positive, in contrast to galactomannan antigen results.