Abstract
This case discusses the pharmacokinetic interaction between metoprolol and diphenhydramine. Metoprolol is a cytochrome P450 2D6 substrate. Diphenhydramine is a 2D6 inhibitor. Coadministration results in metoprolol toxicity.
Cite
CITATION STYLE
APA
Wittwer, E. D., & Sprung, J. (2015). Better sleep but slower heart: Metoprolol, diphenhydramine, CYP2D6. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 581–584). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_128
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