Telomerase Complex from Yeast Saccharomyces cerevisiae Contains a Biotinylated Component

  • Shcherbakova D
  • Zvereva M
  • Dontsova O
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Abstract

Telomerase adds telomeric repeats to single-stranded DNA at the ends of the chromosomes. This enzyme is a ribonucleoprotein complex. Telomerase from yeast Saccharomyces cerevisiae consists of TLC1 RNA, which serves as a template for the synthesis of telomeric repeats, telomerase reverse transcriptase Est2p, and a number of accessory proteins (Est1p, Est3p, Ku70/Ku80, and Sm-complex). We found that the yeast telomerase complex contains a biotinylated component. The telomerase fraction containing biotinylated protein is active in vitro and constitutes a small part of the total amount of active telomerase isolated from cells. We speculate about the nature of the biotinylated component.

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Shcherbakova, D. M., Zvereva, M. I., & Dontsova, O. A. (2009). Telomerase Complex from Yeast Saccharomyces cerevisiae Contains a Biotinylated Component. Acta Naturae, 1(2), 81–85. https://doi.org/10.32607/20758251-2009-1-2-81-85

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