Neutrophil maturity in cancer

3Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display anti-and pro-tumor properties. Accumulating evidence indicates that neutrophils display diversity in their phenotype resulting from functional plasticity and/or changes to granulopoiesis. In cancer, neutrophils at a range of maturation stages can be identified in the blood and tissues (i.e., outside of their developmental niche). The functional capacity of neutrophils at different states of maturation is poorly understood resulting from challenges in their isolation, identification, and investigation. Thus, the impact of neutrophil maturity on cancer progression and therapy remains enigmatic. In this review, we discuss the identification, prevalence, and function of immature and mature neutrophils in cancer and the potential impact of this on tumor progression and cancer therapy.

Cite

CITATION STYLE

APA

Mackey, J. B. G., Coffelt, S. B., & Carlin, L. M. (2019). Neutrophil maturity in cancer. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2019.01912

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free